Vitamin D and Diabetes-Can We Prevent it?
This presentation is well over half an hour long so allow time. You may decide because it is a fairly complex issue it would be best to download it so you may listen to, and examine the charts several times.
While the talk is for health professionals and vitamin d scientists I am sure most people here will gain a lot from watching it.
It is important not only to prevent Diabetes or delay it's onset but also those with diabetes need to understand how improving D3 status improves glucose metabolism and insulin sensitivity.
When you have considered that video you may also find this one adds to your knowledge. There is a section on Diabetes that adds to the previous video.
Vitamin D and Cardiovascular Disease Prevention another in the series of Vitamin D talks sponsored by Grassrootshealth.org and hosted by University of Califorian television.
Vitamin D and Diabetes-Can We Prevent it?
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tedhutchinson
- Posts: 254
- Joined: Tue Nov 15, 2005 11:02 am
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tedhutchinson
- Posts: 254
- Joined: Tue Nov 15, 2005 11:02 am
Vitamin D and Diabetes-Can We Prevent it?
As the number of times this important video has been viewed is increasing so very slowly, I hope you don't mind if I put a brief résumé of it here so those who haven't got access to broadband or have limited access and are reluctant to use it watching You Tube videos have a basic understanding of Frank Garland's thesis.
In this half hour video Frank Garland discusses the relationship between low vitamin d status and Type One diabetes incidence.
It is an extremely important summary of the evidence we have to date that will enable those who understand this evidence to not only take effective action to lower the risk of Type One incidence but also to possibly modify the course of their type one diabetes.
Dr Garland shows us a chart of Type One incidence in Finland from 1965 to date and points out the connection between changes in Vitamin d intake and the impact these changes have had on the rate of incidence of Type I.
He compares the incidence rate of those children who had no D3 supplementation with those who had supplements sometimes and those who had supplements regularly.
Dr Garland spends some time talking about the Eurodiab trial
of 16000+children under 15 started in 1988 in Europe
He then takes this information and looks at it in terms of
Latitude,
ultraviolet radiation,
season and
person (race, BMI, exercise)
there are slides that cover each of those points that he discusses in detail.
He then spends some time explaining the mechanism by which Vitamin D status may have this impact on diabetes incidence and produces some interesting slides that may help people new to this topic understand what may be happening.
I can't really do justice to this talk in a brief summary here but I do hope people follow the link above and spend time trying to understand the science he is detailing.
The important conclusion is that raising Vitamin d status above 40ng 100nmol/l and ideally to around 60ng/mL 150nmol/l will have a major impact on the incidence of Type One and will also improve the prospects for everyone particularly those with diabetes. He suggest 1000iu for children and 2000iu/d for adults BUT for UK readers we have t0 grasp the facts of Vitamin d mechanics. Each 1000iu/extra daily raises status 25nmol/l ~ 10ng. 2000iu/daily for the average adult achieves only 50ng/mL rise or when added to current average 35nmol/l (Feb) status 85nmol/l still under the minimum tarrget of 40ng 100nmol/l.
To attain and maintain a status nearer the ideal for least chronic disease incidence 60ng 150nmol/l an intake of 5000iu/d for Females or 6000iu/d for males is the typical minimum dose needed in latitude for the UK.
The only way you will know what your body requires is to use the above minimum for 3months then 25(OH)D test (see thread on cheap testing) and then adjust the dose to the higher amount that probably will be needed.
In this half hour video Frank Garland discusses the relationship between low vitamin d status and Type One diabetes incidence.
It is an extremely important summary of the evidence we have to date that will enable those who understand this evidence to not only take effective action to lower the risk of Type One incidence but also to possibly modify the course of their type one diabetes.
Dr Garland shows us a chart of Type One incidence in Finland from 1965 to date and points out the connection between changes in Vitamin d intake and the impact these changes have had on the rate of incidence of Type I.
He compares the incidence rate of those children who had no D3 supplementation with those who had supplements sometimes and those who had supplements regularly.
Dr Garland spends some time talking about the Eurodiab trial
of 16000+children under 15 started in 1988 in Europe
He then takes this information and looks at it in terms of
Latitude,
ultraviolet radiation,
season and
person (race, BMI, exercise)
there are slides that cover each of those points that he discusses in detail.
He then spends some time explaining the mechanism by which Vitamin D status may have this impact on diabetes incidence and produces some interesting slides that may help people new to this topic understand what may be happening.
I can't really do justice to this talk in a brief summary here but I do hope people follow the link above and spend time trying to understand the science he is detailing.
The important conclusion is that raising Vitamin d status above 40ng 100nmol/l and ideally to around 60ng/mL 150nmol/l will have a major impact on the incidence of Type One and will also improve the prospects for everyone particularly those with diabetes. He suggest 1000iu for children and 2000iu/d for adults BUT for UK readers we have t0 grasp the facts of Vitamin d mechanics. Each 1000iu/extra daily raises status 25nmol/l ~ 10ng. 2000iu/daily for the average adult achieves only 50ng/mL rise or when added to current average 35nmol/l (Feb) status 85nmol/l still under the minimum tarrget of 40ng 100nmol/l.
To attain and maintain a status nearer the ideal for least chronic disease incidence 60ng 150nmol/l an intake of 5000iu/d for Females or 6000iu/d for males is the typical minimum dose needed in latitude for the UK.
The only way you will know what your body requires is to use the above minimum for 3months then 25(OH)D test (see thread on cheap testing) and then adjust the dose to the higher amount that probably will be needed.
Vitamin D and Diabetes-Can We Prevent it?
Ted, why does my pharmacy offer a 100% Recommended Daily Allowance of 200 IU?
It always seems to me that you're putting forward thirty-times doses of Vitamin D as a cure for an assortment of ills which traditional medical knowledge has considered unrelated to it.
Vitamin D has a half-life of three weeks or so?
Is the human body, permanently naked under a tropical sun, capable of producing the equivalent of 6000 IU a day input through normal sunlight and food intake, or is your 6000 IU an unnaturally high level even for that extreme state of affairs?
It always seems to me that you're putting forward thirty-times doses of Vitamin D as a cure for an assortment of ills which traditional medical knowledge has considered unrelated to it.
Vitamin D has a half-life of three weeks or so?
Is the human body, permanently naked under a tropical sun, capable of producing the equivalent of 6000 IU a day input through normal sunlight and food intake, or is your 6000 IU an unnaturally high level even for that extreme state of affairs?
Nullius in verba ... ☎||||||||||| ... To Fate I sue, of other means bereft, the only refuge for the wretched left.
When flower power came along I stood for Human Rights, marched around for peace and freedom, had some nooky every night - we took it serious.
Who has a spare two minutes to play in this month's FG Trivia game! ... My other OS is Slackware.
When flower power came along I stood for Human Rights, marched around for peace and freedom, had some nooky every night - we took it serious.
Who has a spare two minutes to play in this month's FG Trivia game! ... My other OS is Slackware.
-
tedhutchinson
- Posts: 254
- Joined: Tue Nov 15, 2005 11:02 am
Vitamin D and Diabetes-Can We Prevent it?
spot;1148332 wrote: Ted, why does my pharmacy offer a 100% Recommended Daily Allowance of 200 IU?Because a lot of people don't understand that the RDA was not intended to be the optimum amount of vitamin d the body needed for good health. At the time it was originally set all they knew was that 200iu/d prevented rickets so it was assumed that was sufficient for everything else. The has been a lot of research, particularly over the last 10 years and it's been very exciting and this new research shows that if we raised status to the levels the human body naturally acquires given full body sun exposure then we can avoid a lot of other conditions See this chart of Disease Incidence Prevention by Serum 25(OH)D Level] and you can see how raising your vitamin d status to the same as your body would like to acquire if you lived as humans evolved to live, would prevent lots of unnecessary disease and illness.
It always seems to me that you're putting forward thirty-times doses of Vitamin D as a cure for an assortment of ills which traditional medical knowledge has considered unrelated to it. The problem is ignorance. Until recently we did not know how to find Vitamin D receptors. With modern techniques they can now find VDR and when they find VDR in in different tissue sites 900+ now they know that particular tissue uses Vitamin D to control some of it's functions. They then have to work out what a difference switching on or switching off that VDR does. It all takes time and costs money and of course because vitamin D is free from sunlight and not something anyone can profit from, because it is a natural substance it can't be patented, and because it's made from the biproducts of the wool/fish industry it's always going to be dirt cheap. No one can profit so big pharma aren't going to pay for money to research it.
So there's still loads to learn. I'm learning something new every day. I've been touting the fact that these VDR perform 200 different genomic actions as gospel for some time but I learn't recently that this 200 different actions is only related to heart and vascular function. So if you add on all the rest it's going to be a huge understatement of how important vitamin d actually is.
Vitamin D and Cardiovascular Disease Prevention this explains about the role in heart disease.
Vitamin D has a half-life of three weeks or so? Indeed that is why for most people (apart from breast feeding mothers and possibly pregnant women) it doesn't matter terribly if you only take your D3 once a fortnight or weekly or daily so long as over the 3 weeks you consume an appropriate amount in relation to your size, your latitude and your skin colour.
Weight wise you need 1000iu per 30lbs or 100iu per 3lbs per day.
From October through to March living in the northern hemisphere means you don't get any Vitamin D from sunshine so all has to come from supplements or sunbed exposure, diet can only contribute 10% of daily need.
People with darker skins get less from sunlight particularly in the north of the northern hemisphere so need more from supplements.
On average a woman living above latitude 40N requires 5000iu/d extra to reach 150nmol/l 60ng and a man 6000iu/daily to achieve the same.
A 25(OH)D test after you have been supplementing for 90 days will tell you if you need more. To work that out you need to use an extra 1000/d for each 10ng or 25nmol/l more you need to go up.
uote]Is the human body, permanently naked under a tropical sun, capable of producing the equivalent of 6000 IU a day input through normal sunlight and food intake, or is your 6000 IU an unnaturally high level even for that extreme state of affairs?Hollis shows here how people outside all day providing they take their clothes off, maintain a status around 60ng 150nmol/l
and the second table shows how the same levels can be achieved with 6000iu/daily.
This was when we learnt that the human body uses 300~5000iu daily.
But we also have to have a bit in reserve to prime the pump and ensure the vitamin d hormone when needed is able to be applied with sufficient power. To do this you need some D3 in store to match the circulating 25(OH)D so as the body only starts storing D3 above 100nmol/l 40 ng that means you MUST have an intake above 4000iu/daily or you body won't work as efficiently as it might. If you look at the plots in the HOLLIS paper you'll see how you need a high circulating level to raise your level of stored D3, so with a half life of 3 weeks you need a mega store to get through the winter.
How many iu's at 5000iu daily needed from last day in Sept to last day in Feb?
How many 21 day periods from Sept to Feb?
If you bank account depleted at the rate of 50% every 21days and you also hd to spend $5000 every single day how much money would you need at the end of Sept to get through to the end of Feb still with money in the bank?
It always seems to me that you're putting forward thirty-times doses of Vitamin D as a cure for an assortment of ills which traditional medical knowledge has considered unrelated to it. The problem is ignorance. Until recently we did not know how to find Vitamin D receptors. With modern techniques they can now find VDR and when they find VDR in in different tissue sites 900+ now they know that particular tissue uses Vitamin D to control some of it's functions. They then have to work out what a difference switching on or switching off that VDR does. It all takes time and costs money and of course because vitamin D is free from sunlight and not something anyone can profit from, because it is a natural substance it can't be patented, and because it's made from the biproducts of the wool/fish industry it's always going to be dirt cheap. No one can profit so big pharma aren't going to pay for money to research it.
So there's still loads to learn. I'm learning something new every day. I've been touting the fact that these VDR perform 200 different genomic actions as gospel for some time but I learn't recently that this 200 different actions is only related to heart and vascular function. So if you add on all the rest it's going to be a huge understatement of how important vitamin d actually is.
Vitamin D and Cardiovascular Disease Prevention this explains about the role in heart disease.
Vitamin D has a half-life of three weeks or so? Indeed that is why for most people (apart from breast feeding mothers and possibly pregnant women) it doesn't matter terribly if you only take your D3 once a fortnight or weekly or daily so long as over the 3 weeks you consume an appropriate amount in relation to your size, your latitude and your skin colour.
Weight wise you need 1000iu per 30lbs or 100iu per 3lbs per day.
From October through to March living in the northern hemisphere means you don't get any Vitamin D from sunshine so all has to come from supplements or sunbed exposure, diet can only contribute 10% of daily need.
People with darker skins get less from sunlight particularly in the north of the northern hemisphere so need more from supplements.
On average a woman living above latitude 40N requires 5000iu/d extra to reach 150nmol/l 60ng and a man 6000iu/daily to achieve the same.
A 25(OH)D test after you have been supplementing for 90 days will tell you if you need more. To work that out you need to use an extra 1000/d for each 10ng or 25nmol/l more you need to go up.
uote]Is the human body, permanently naked under a tropical sun, capable of producing the equivalent of 6000 IU a day input through normal sunlight and food intake, or is your 6000 IU an unnaturally high level even for that extreme state of affairs?Hollis shows here how people outside all day providing they take their clothes off, maintain a status around 60ng 150nmol/l
and the second table shows how the same levels can be achieved with 6000iu/daily.
This was when we learnt that the human body uses 300~5000iu daily.
But we also have to have a bit in reserve to prime the pump and ensure the vitamin d hormone when needed is able to be applied with sufficient power. To do this you need some D3 in store to match the circulating 25(OH)D so as the body only starts storing D3 above 100nmol/l 40 ng that means you MUST have an intake above 4000iu/daily or you body won't work as efficiently as it might. If you look at the plots in the HOLLIS paper you'll see how you need a high circulating level to raise your level of stored D3, so with a half life of 3 weeks you need a mega store to get through the winter.
How many iu's at 5000iu daily needed from last day in Sept to last day in Feb?
How many 21 day periods from Sept to Feb?
If you bank account depleted at the rate of 50% every 21days and you also hd to spend $5000 every single day how much money would you need at the end of Sept to get through to the end of Feb still with money in the bank?
Vitamin D and Diabetes-Can We Prevent it?
That's good. Now I understand where you're coming from. Yes it's a natural level to maintain - I'd thought it couldn't be. Given that it's a natural level to maintain I agree it's a desirable state of affairs to achieve.
What's the price tag? Assuming some plant somewhere is churning this stuff out by the metric ton and the world isn't going to go short, what do they charge for oral tablets capable of maintaining that serum level? Presumably I ought to be looking for 150 microgram daily tablets year round since, the way I dress and the number of times I step out of the house in daylight, I'm making none of it myself biologically whatever the weather's like.
What's the price tag? Assuming some plant somewhere is churning this stuff out by the metric ton and the world isn't going to go short, what do they charge for oral tablets capable of maintaining that serum level? Presumably I ought to be looking for 150 microgram daily tablets year round since, the way I dress and the number of times I step out of the house in daylight, I'm making none of it myself biologically whatever the weather's like.
Nullius in verba ... ☎||||||||||| ... To Fate I sue, of other means bereft, the only refuge for the wretched left.
When flower power came along I stood for Human Rights, marched around for peace and freedom, had some nooky every night - we took it serious.
Who has a spare two minutes to play in this month's FG Trivia game! ... My other OS is Slackware.
When flower power came along I stood for Human Rights, marched around for peace and freedom, had some nooky every night - we took it serious.
Who has a spare two minutes to play in this month's FG Trivia game! ... My other OS is Slackware.
-
tedhutchinson
- Posts: 254
- Joined: Tue Nov 15, 2005 11:02 am
Vitamin D and Diabetes-Can We Prevent it?
spot;1148618 wrote: What's the price tag? The cheapest I'm aware of is now foods 5000iubuy 3 pots. use code WAB666 save $5.
Then give your rewards code to all your friends family relations, workmates anyone you actually care about who you think would benefit from using one of the world's cheapest sources of good quality named brand supplements.
Consumerlabes rate IHERB as their best ETAILER so passing on your rewards code not only gives them a $5 discount but enables you to benefit from further discounts to be credited to your account. All right I know it's just a trivial amount and nothing to get excited about but for people who live in the UK it is more of a big deal as we have to pay tax on orders over £18 and our Post Office are absolute extortionists they charge £8 just to collect £3 so everything you can do to get credits that will lower your bill before post and packing is well worth while.
Then give your rewards code to all your friends family relations, workmates anyone you actually care about who you think would benefit from using one of the world's cheapest sources of good quality named brand supplements.
Consumerlabes rate IHERB as their best ETAILER so passing on your rewards code not only gives them a $5 discount but enables you to benefit from further discounts to be credited to your account. All right I know it's just a trivial amount and nothing to get excited about but for people who live in the UK it is more of a big deal as we have to pay tax on orders over £18 and our Post Office are absolute extortionists they charge £8 just to collect £3 so everything you can do to get credits that will lower your bill before post and packing is well worth while.
Vitamin D and Diabetes-Can We Prevent it?
That, Ted, is surprisingly cheap. It's been a good thread, thank you.
Nullius in verba ... ☎||||||||||| ... To Fate I sue, of other means bereft, the only refuge for the wretched left.
When flower power came along I stood for Human Rights, marched around for peace and freedom, had some nooky every night - we took it serious.
Who has a spare two minutes to play in this month's FG Trivia game! ... My other OS is Slackware.
When flower power came along I stood for Human Rights, marched around for peace and freedom, had some nooky every night - we took it serious.
Who has a spare two minutes to play in this month's FG Trivia game! ... My other OS is Slackware.
-
tedhutchinson
- Posts: 254
- Joined: Tue Nov 15, 2005 11:02 am
Vitamin D and Diabetes-Can We Prevent it?
I thought you may be interested in this slide from the above video.
It shows the incidence reduction that comes from either not using supplements that is the reference range, using them irregularly or using the every day.
It seems to me that for 5p daily you buy youself and your family as significant perhaps even more that 80% reduction in type one diabetes incidence for that money if you use them regularly.
It shows the incidence reduction that comes from either not using supplements that is the reference range, using them irregularly or using the every day.
It seems to me that for 5p daily you buy youself and your family as significant perhaps even more that 80% reduction in type one diabetes incidence for that money if you use them regularly.
-
tedhutchinson
- Posts: 254
- Joined: Tue Nov 15, 2005 11:02 am
Vitamin D and Diabetes-Can We Prevent it?
CaroleBaggerlyVideo
http://i1.ytimg.com/vi/0O3L77kgU24/default.jpg
Vitamin D basics including how to do the home blood spot test. Ideal summary for beginners.
She kept talking about $40 for the test, the site she links to www.ordervitamindtest.org is still saying $30 so if you are hard up then you'd better order quick as I suspect they intend to raise the price a little.
http://i1.ytimg.com/vi/0O3L77kgU24/default.jpg
Vitamin D basics including how to do the home blood spot test. Ideal summary for beginners.
She kept talking about $40 for the test, the site she links to www.ordervitamindtest.org is still saying $30 so if you are hard up then you'd better order quick as I suspect they intend to raise the price a little.